Indole compound

To provide a compound useful as a MT1 and/or MT2 receptor agonist. The present inventors have studied on MT1 and/or MT2 receptor agonists, and have confirmed that indole compounds have the activity. As a result, the present invention is accomplished. That is, the present invention has a MT1 and/or M...

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Main Authors KANAYAMA, TAKATOSHI, SHIMIZU, TAKAFUMI, SAITO, TOMOYUKI, MORI, CHIHARU, MATSUI, SHIGEO, TANAKA, HIROAKI, YOKOYAMA, KAZUHIRO, MATSUMOTO, SHUNICHIRO
Format Patent
LanguageChinese
English
Published 16.05.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:To provide a compound useful as a MT1 and/or MT2 receptor agonist. The present inventors have studied on MT1 and/or MT2 receptor agonists, and have confirmed that indole compounds have the activity. As a result, the present invention is accomplished. That is, the present invention has a MT1 and/or MT2 receptor agonistic activity and has a low ability of migrating into the central nervous system. Therefore, the compound or a salt thereof can be used as a peripheral MT1 and/or MT2 receptor agonist, and therefore can be used as a therapeutic and/or prophylactic agent for urinary incontinence, particularly stress urinary incontinence and mixed urinary incontinence.
Bibliography:Application Number: TW20154101079