Process of producing cycloalkylcarboxamido-indole compounds

The present invention features processes for preparing compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1), useful for treating CFTR mediated diseases such as cystic f...

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Main Authors LITTLER, BENJAMIN JOSEPH, ROSE, PETER JAMISON, HUGHES, ROBERT MICHAEL, JUNG, YOUNGUN, LEE, ELAINE CHUNGMIN, HARRISON, CRISTIAN, TANOURY, GERALD J, BELMONT, DANIEL T, SIESEL, DAVID ANDREW
Format Patent
LanguageChinese
English
Published 01.04.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Abstract The present invention features processes for preparing compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1), useful for treating CFTR mediated diseases such as cystic fibrosis.
AbstractList The present invention features processes for preparing compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1), useful for treating CFTR mediated diseases such as cystic fibrosis.
Author JUNG, YOUNGUN
ROSE, PETER JAMISON
HARRISON, CRISTIAN
BELMONT, DANIEL T
LEE, ELAINE CHUNGMIN
SIESEL, DAVID ANDREW
TANOURY, GERALD J
LITTLER, BENJAMIN JOSEPH
HUGHES, ROBERT MICHAEL
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– fullname: LEE, ELAINE CHUNGMIN
– fullname: HARRISON, CRISTIAN
– fullname: TANOURY, GERALD J
– fullname: BELMONT, DANIEL T
– fullname: SIESEL, DAVID ANDREW
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Snippet The present invention features processes for preparing compounds, such as...
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HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title Process of producing cycloalkylcarboxamido-indole compounds
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