COMPUESTOS DE HETEROARILO O ARILO BIC�CLICOS FUSIONADOS

• Main Authors: ZAPF CHRISTOPH WOLFGANG, ANDERSON DAVID RANDOLPH, DEHNHARDT CHRISTOPH MARTIN, LOWE MICAHEL DENNIS, BUNNAGE MARK EDWARD, VARGAS RICHARD, PAPAIOANNOU NIKOLAOS, LEE ARTHUR, LEE KATHERINE LIN, STROHBACH JOSEPH WALTER, TRZUPEK JOHN DAVID, WANG XIAOLUN, PATNY AKSHAY, LOVERING FRANK ELDRIDGE, PIERCE BETSY SUSAN, WRIGHT STEPHEN WAYNE, GOLDBERG JOEL ADAM, SAIAH EDDINE, HEPWORTH DAVID, CURRAN KEVIN JOSEPH, HORNGIN HUANG, MATHIAS JOHN PAUL, GAVRIN LORI KRIM, HAN SEUNGIL
• Format: Patent
• Language: Spanish
• Published: 28.03.2017
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

SE DESCRIBEN COMPUESTOS, TAUTÃ"MEROS Y SALES DE ESTOS ACEPTABLES DESDE EL PUNTO DE VISTA FARMACÉUTICO, EN DONDE LOS COMPUESTOS TIENEN LA ESTRUCTURA DE LA FÃ"RMULA LA: (VER FORMULA); COMO SE DEFINIERON EN LA MEMORIA DESCRIPTIVA. TAMBIÉN SE DESCRIBEN COMPOSICIONES FARMACÉUTICAS, MÉTODOS DE TRATAMIENTO, MÉTODOS DE SÃ�NTESIS E INTERMEDIARIOS CORRESPONDIENTES Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula,as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment of autoimmune and inflammatory diseases associated with Interleukin-1 Receptor Associated Kinase (IRAK), methods of synthesis, and intermediates are also disclosed.