Method for making quinolone carboxylic acids or naphthyridine car boxylic acids in free base form

• Main Authors: PORTER KENNETH THOMAS, WEMPLE JAMES NORTON, DOZEMAN GARY JAY
• Format: Patent
• Language: English; Slovak
• Published: 06.11.2002
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides a method of making quinolone carboxylic acids or naphthyridine carboxylic acids in free base form, the method comprising dissolving a quinolone carboxylic acid salt or naphthyridine carboxylic acid salt in a solvent system to form a solution; combining the solution containing the quinolone carboxylic acid salt or naphthyridine carboxylic acid salt with a calcium salt in an amount in the range of about 0.01 % to about 5.0 % by weight of the quinolone carboxylic acid salt or naphthyridine carboxylic acid salt and a base, the combination resulting in the formation of a precipitate; and collecting the precipitate. Also provided is a solid bulk pharmaceutical chemical composition which is the product resulting from the precipitation. Spôsob prípravy chinolónkarboxylových kyselín alebo naftyridínkarboxylových kyselín vo voľnej bázickej forme, ktorý zahŕňa rozpustenie soli chinolónkarboxylovej kyseliny alebo soli naftyridínkarboxylovej kyseliny v rozpúšťadlovom systéme pri vzniku roztoku; zlúčenie roztoku obsahujúceho soľ kyseliny chinolónkarboxylovej alebo soľ kyseliny naftyridínkarboxylovej s vápenatou soľou, ktorej množstvo predstavuje 0,01 hmotn. % až 5,0 hmotn. % soli chinolónkarboxylovej kyseliny alebo soli naftyridínkarboxylovej kyseliny, a bázy, pričom toto zlúčenie má za následok vznik zrazeniny; a izolovanie zrazeniny.ŕ