ANTIBODIES THAT SPECIFICALLY BIND TO TL1A

• Main Authors: POLLARD Matthew, COOKSEY Bridget Ann, PANDE Vanya, DOYLE Anthony G, POULTON Lynn Dorothy, CLARKE Adam William
• Format: Patent
• Language: English; Slovenian
• Published: 30.10.2020
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Recombinantly expressed variant antibodies that have enhanced affinity for TL1A and enhanced potency relative to the parent antibody from which they were derived are provided. The antibodies inhibit the interaction between TL1A and the death receptor 3 (DR3). The antibodies, or a composition thereof...