COMPOSITIONS COMPRISING (S)-2-AMINO-1-(4-CHLOROPHENYL)-1-Š4-(1H-PYRAZOL-4-YL)-PHENYL -ETHANOL AS MODULATOR OF PROTEIN KINASES

• Main Authors: FREDERICKSON MARTYN, GRIMSHAW KYLA MERRIOM, WOODHEAD STEVEN JOHN, REES DAVID CHARLES
• Format: Patent
• Language: English; Slovenian
• Published: 31.12.2014
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides a composition comprising ( S ) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, wherein the composition is either substantially free of ( R ) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol or the composition contains a mixture of the ( S ) and ( R ) enantiomers in which the ( S ) enantiomer predominates. Also provided are processes for the preparation of the ( S ) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, novel process intermediates and methods for making the novel process intermediates.