8-CHLORO-2,3-BENZODIAZEPINE DERIVATIVES

The invention relates to new 8-chloro-2,3-benzodiazepine derivatives of the general formula (I), wherein R stands for a lower alkyl group or a group of the general formula -NH-R′, wherein R′ stands for a lower alkyl or a lower cycloalkyl group), and pharmaceutically acceptable acid addition salts th...

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Main Authors SZENASI GABOR, VEGH MIKLOS, SZUCS GYULA, SZABO GEZA, BARKOCZY JOZSEF, LING ISTVAN, GIGLER GABOR, KERTESZ SZABOLCS, SIMIG GYULA, HARSING LASZLO GABOR
Format Patent
LanguageEnglish
Slovenian
Published 30.04.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Abstract The invention relates to new 8-chloro-2,3-benzodiazepine derivatives of the general formula (I), wherein R stands for a lower alkyl group or a group of the general formula -NH-R′, wherein R′ stands for a lower alkyl or a lower cycloalkyl group), and pharmaceutically acceptable acid addition salts thereof. The invention also encompasses a process for the preparation of said compounds, pharmaceutical compositions containing them and new intermediates useful for the preparation of the new 8-chloro-2,3-benzodiazepine derivatives. The compounds according to the invention possess AMPA/kainate receptor inhibiting activity.
AbstractList The invention relates to new 8-chloro-2,3-benzodiazepine derivatives of the general formula (I), wherein R stands for a lower alkyl group or a group of the general formula -NH-R′, wherein R′ stands for a lower alkyl or a lower cycloalkyl group), and pharmaceutically acceptable acid addition salts thereof. The invention also encompasses a process for the preparation of said compounds, pharmaceutical compositions containing them and new intermediates useful for the preparation of the new 8-chloro-2,3-benzodiazepine derivatives. The compounds according to the invention possess AMPA/kainate receptor inhibiting activity.
Author KERTESZ SZABOLCS
GIGLER GABOR
VEGH MIKLOS
LING ISTVAN
SIMIG GYULA
SZUCS GYULA
SZABO GEZA
SZENASI GABOR
BARKOCZY JOZSEF
HARSING LASZLO GABOR
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– fullname: LING ISTVAN
– fullname: GIGLER GABOR
– fullname: KERTESZ SZABOLCS
– fullname: SIMIG GYULA
– fullname: HARSING LASZLO GABOR
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Snippet The invention relates to new 8-chloro-2,3-benzodiazepine derivatives of the general formula (I), wherein R stands for a lower alkyl group or a group of the...
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HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Title 8-CHLORO-2,3-BENZODIAZEPINE DERIVATIVES
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