A process and intermediate compounds for the preparation of amlodipine benzene sulphonate

A subject matter of the invention is a process for preparing 3-ÄethylÜ-5-ÄmethylÜ-2-Ä2'-(aminoethoxy)-methylÜ-4--Ä2''-(chloro)-phen ylÜ-6-ÄmethylÜ-1,4-di-ÄhydroÜ-pyridine-3,5-di-ÄcarboxylateÜ benzenesulfonic acid salt of Formula in which 3-ÄethylÜ-5-ÄmethylÜ-2-Ä2'-(yl)-ethoxy-met...

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Main Authors BLASKO GABOR DR, KOVANYI GYOERGYI LAX DR, NAGY KALMAN DR, KRASZNAI GYOERGY, TOEMPE PETER DR, NEMETH NORBERT, BOZSING DANIEL DR, SIMIG GYULA DR, VERECZKEY GYOERGYI DONATH, NEMET GABOR
Format Patent
LanguageEnglish
Slovenian
Published 31.08.2002
Edition7
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Summary:A subject matter of the invention is a process for preparing 3-ÄethylÜ-5-ÄmethylÜ-2-Ä2'-(aminoethoxy)-methylÜ-4--Ä2''-(chloro)-phen ylÜ-6-ÄmethylÜ-1,4-di-ÄhydroÜ-pyridine-3,5-di-ÄcarboxylateÜ benzenesulfonic acid salt of Formula in which 3-ÄethylÜ-5-ÄmethylÜ-2-Ä2'-(yl)-ethoxy-methylÜ-4-Ä2''-(chloro)-phenylÜ -6-ÄmethylÜ-1,4-di-ÄhydroÜ-pyridine-3,5-di-ÄcarboxylateÜ hexaminium iodide of Formula is reacted with benzenesulfonic acid of Formula Several variants comprise also reactions for preparing intermediates leading to the said end product. A further subject matter of the invention are intermediates for preparing the said end product.
Bibliography:Application Number: SI19980030190T