POTASSIUM CHANNEL DRUGS AND THEIR USES

This invention relates to novel multibinding compounds that bind to potassium (K<+>) channels and modulate their activity. The compounds of this invention comprise 2-10 K<+> channel ligands covalently connected by a linker or linkers, wherein the ligands in their monovalent (i.e., unlink...

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Bibliographic Details
Main Authors JACOBSEN JOHN R, GRIFFIN JOHN H, EASTMAN DONNA
Format Patent
LanguageEnglish
Published 17.04.2001
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
TESTING
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Summary:This invention relates to novel multibinding compounds that bind to potassium (K<+>) channels and modulate their activity. The compounds of this invention comprise 2-10 K<+> channel ligands covalently connected by a linker or linkers, wherein the ligands in their monovalent (i.e., unlinked) state bind to one or more types of K<+> channel. The manner of linking the ligands together is such that the multibinding agents thus formed demonstrate an increased biologic and/or therapeutic effect as compared to the same number of unlinked ligands made available for binding to the K<+> channel. The invention also relates to methods of using such compounds and to methods of preparing them. The compounds of this invention are particularly useful for treating diseases and conditions of mammals that are mediated by K<+> channels. Accordingly, this invention also relates to pharmaceutical compositions comprising a pharmaceutically acceptable excipient and an effective amount of a compound of this invention.
Bibliography:Application Number: SG19990002714