SYSTEMS AND METHODS FOR PREDICTING SPECIFIC GENETIC LOCI THAT AFFECT PHENOTYPIC TRAITS

• Main Authors: PELTZ, GARY, ALLEN, USUKA, JONATHAN, ANDREW, LIAO, GUOCHUN
• Format: Patent
• Language: English
• Published: 28.06.2012
• Subjects: BEER; BIOCHEMISTRY; CALCULATING; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; COMPUTING; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; COUNTING; CULTURE MEDIA; ELECTRIC DIGITAL DATA PROCESSING; ENZYMOLOGY; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

OF THE DISCLOSURESYSTEMS AND METHODS FOR PREDICTING SPECIFIC GENETIC LOCI THATAFFECT PHENOTYPIC TRAITSA database of genetic variations is analyzed to produce a haplotype map of the genomefor strains of a single species. A computational method is used to rapidly map complexphenotypes onto the haplotype blocks within the haplotype map. The specific geneticlocus regulating three different biologically important phenotypic traits in mice is identifiedusing these systems and methods.Fig. 2