NLRP3 INFLAMMASOME INHIBITORS

The present invention relates to novel pyridazin-3-yl phenol compounds of Formula (I):wherein R1, R2, R3, R4, R5 and Z are defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical com...

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Main Authors SMITH, Nichola, FOOKS SOLOVAY, Catherine, VELCICKY, Juraj, FARADY, Christopher, MATTES, Henri, GOMMERMANN, Nina, STIEFL, Nikolaus Johannes, VON MATT, Anette, VANGREVELINGHE, Eric, MACKAY, Angela, JANSER, Philipp
Format Patent
LanguageEnglish
Published 30.12.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract The present invention relates to novel pyridazin-3-yl phenol compounds of Formula (I):wherein R1, R2, R3, R4, R5 and Z are defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of diseases and disorders mediated by NLRP3.
AbstractList The present invention relates to novel pyridazin-3-yl phenol compounds of Formula (I):wherein R1, R2, R3, R4, R5 and Z are defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of diseases and disorders mediated by NLRP3.
Author FOOKS SOLOVAY, Catherine
FARADY, Christopher
VELCICKY, Juraj
MACKAY, Angela
SMITH, Nichola
JANSER, Philipp
STIEFL, Nikolaus Johannes
GOMMERMANN, Nina
MATTES, Henri
VON MATT, Anette
VANGREVELINGHE, Eric
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– fullname: FARADY, Christopher
– fullname: MATTES, Henri
– fullname: GOMMERMANN, Nina
– fullname: STIEFL, Nikolaus Johannes
– fullname: VON MATT, Anette
– fullname: VANGREVELINGHE, Eric
– fullname: MACKAY, Angela
– fullname: JANSER, Philipp
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Snippet The present invention relates to novel pyridazin-3-yl phenol compounds of Formula (I):wherein R1, R2, R3, R4, R5 and Z are defined herein, which inhibit...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title NLRP3 INFLAMMASOME INHIBITORS
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