ESCHERICHIA COLI COMPOSITIONS AND METHODS THEREOF

In one aspect, the invention relates to an immunogenic composition comprising modified O-polysaccharide molecules derived from E. coli lipopolysaccharides and conjugates thereof. Multivalent vaccines may be prepared by combining two or more monovalent immunogenic compositions for different E. coli s...

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Main Authors ANDERSON, Annaliesa Sybil, KIM, Jin-Hwan, CHORRO, Laurent Oliver, MERCHANT, Nishith, LOMBERK, Scott Ellis, SINGH, Suddham, CHU, Ling, KODALI, Srinivas, CHEN, Wei, PAN, Rosalind, LOTVIN, Jason Arnold, TAKANE, Karen Kiyoko, DONALD, Robert G. K, PRASAD, Avvari Krishna, RUPPEN, Mark Edward, GU, Jianxin, MORAN, Justin Keith
Format Patent
LanguageEnglish
Published 29.04.2021
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract In one aspect, the invention relates to an immunogenic composition comprising modified O-polysaccharide molecules derived from E. coli lipopolysaccharides and conjugates thereof. Multivalent vaccines may be prepared by combining two or more monovalent immunogenic compositions for different E. coli serotypes. In one embodiment, the modified O-polysaccharide molecules are produced by a recombinant bacterium that includes a wzz gene.
AbstractList In one aspect, the invention relates to an immunogenic composition comprising modified O-polysaccharide molecules derived from E. coli lipopolysaccharides and conjugates thereof. Multivalent vaccines may be prepared by combining two or more monovalent immunogenic compositions for different E. coli serotypes. In one embodiment, the modified O-polysaccharide molecules are produced by a recombinant bacterium that includes a wzz gene.
Author CHORRO, Laurent Oliver
KODALI, Srinivas
MORAN, Justin Keith
KIM, Jin-Hwan
SINGH, Suddham
PRASAD, Avvari Krishna
MERCHANT, Nishith
PAN, Rosalind
ANDERSON, Annaliesa Sybil
DONALD, Robert G. K
CHU, Ling
GU, Jianxin
LOMBERK, Scott Ellis
LOTVIN, Jason Arnold
CHEN, Wei
RUPPEN, Mark Edward
TAKANE, Karen Kiyoko
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– fullname: SINGH, Suddham
– fullname: CHU, Ling
– fullname: KODALI, Srinivas
– fullname: CHEN, Wei
– fullname: PAN, Rosalind
– fullname: LOTVIN, Jason Arnold
– fullname: TAKANE, Karen Kiyoko
– fullname: DONALD, Robert G. K
– fullname: PRASAD, Avvari Krishna
– fullname: RUPPEN, Mark Edward
– fullname: GU, Jianxin
– fullname: MORAN, Justin Keith
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Snippet In one aspect, the invention relates to an immunogenic composition comprising modified O-polysaccharide molecules derived from E. coli lipopolysaccharides and...
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SubjectTerms CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title ESCHERICHIA COLI COMPOSITIONS AND METHODS THEREOF
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