WATER SOLUBLE POLYCARBONATES FOR MEDICAL APPLICATIONS
Water soluble biodegradable polymers were prepared by an organoacid catalyzed ring opening polymerization (ROP) of a cyclic carbonate monomer bearing an active ester side chain. The initial polymer comprising an active ester side chain was treated with an amino-alcohol, which transformed the active...
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| Main Authors | , , , , |
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| Format | Patent |
| Language | English |
| Published |
29.06.2017
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Water soluble biodegradable polymers were prepared by an organoacid catalyzed ring opening polymerization (ROP) of a cyclic carbonate monomer bearing an active ester side chain. The initial polymer comprising an active ester side chain was treated with an amino-alcohol, which transformed the active ester groups to N-substituted amide groups bearing mono-hydroxy alkyl groups and/or dihydroxy alkyl groups, thereby forming the water soluble polymers. The water-soluble polymers are non-toxic and exhibit stealth properties in buffered serum solution. |
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| AbstractList | Water soluble biodegradable polymers were prepared by an organoacid catalyzed ring opening polymerization (ROP) of a cyclic carbonate monomer bearing an active ester side chain. The initial polymer comprising an active ester side chain was treated with an amino-alcohol, which transformed the active ester groups to N-substituted amide groups bearing mono-hydroxy alkyl groups and/or dihydroxy alkyl groups, thereby forming the water soluble polymers. The water-soluble polymers are non-toxic and exhibit stealth properties in buffered serum solution. |
| Author | ENGLER, Amanda, Catherine COADY, Daniel, Joseph HEDRICK, James YANG, Yi Yan KE, Xiyu |
| Author_xml | – fullname: COADY, Daniel, Joseph – fullname: ENGLER, Amanda, Catherine – fullname: KE, Xiyu – fullname: YANG, Yi Yan – fullname: HEDRICK, James |
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| Snippet | Water soluble biodegradable polymers were prepared by an organoacid catalyzed ring opening polymerization (ROP) of a cyclic carbonate monomer bearing an active... |
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| SubjectTerms | CHEMISTRY COMPOSITIONS BASED THEREON HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR PREPARATION OR CHEMICAL WORKING-UP |
| Title | WATER SOLUBLE POLYCARBONATES FOR MEDICAL APPLICATIONS |
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