CO-CRYSTALS OF (S)-N-METHYL-8-(1-((2'-METHYL-[4,5'-BIPYRIMIDIN]-6-YL)AMINO)PROPAN-2-YL)QUINOLINE-4-CARBOXAMIDE AND DEUTERATED DERIVATIVES THEREOF AS DNA-PK INHIBITORS

The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R 1 and R 2 is H or 2 H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within t...

Full description

Saved in:
Bibliographic Details
Main Authors STROHMEIER, MARK, MUDUNURI, PRAVEEN, VAN ALSTEN, JOHN GREGG, KADIYALA, IRINA NIKOLAEVNA, ZHANG, YUEGANG, WALDO, MICHAEL, STAVROPOULOS, KATHY, NTI-ADDAE, KWAME, WIREDU, O'NEIL, SIMON, ADAM, SONG, BIN, NAVAMAL, METTACHIT
Format Patent
LanguageEnglish
Published 30.05.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

Abstract The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R 1 and R 2 is H or 2 H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.
AbstractList The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R 1 and R 2 is H or 2 H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.
Author NTI-ADDAE, KWAME, WIREDU
WALDO, MICHAEL
NAVAMAL, METTACHIT
SONG, BIN
KADIYALA, IRINA NIKOLAEVNA
O'NEIL, SIMON, ADAM
STROHMEIER, MARK
STAVROPOULOS, KATHY
ZHANG, YUEGANG
VAN ALSTEN, JOHN GREGG
MUDUNURI, PRAVEEN
Author_xml – fullname: STROHMEIER, MARK
– fullname: MUDUNURI, PRAVEEN
– fullname: VAN ALSTEN, JOHN GREGG
– fullname: KADIYALA, IRINA NIKOLAEVNA
– fullname: ZHANG, YUEGANG
– fullname: WALDO, MICHAEL
– fullname: STAVROPOULOS, KATHY
– fullname: NTI-ADDAE, KWAME, WIREDU
– fullname: O'NEIL, SIMON, ADAM
– fullname: SONG, BIN
– fullname: NAVAMAL, METTACHIT
BookMark eNqNjsFKw0AURbOoC6v-wywKTcAHzdiGunzJvJpHk5lxZloaREqRcSVpoX6T32kKuu_qHg5nccfJqD_28Tb5qQxUrvMBGy_MSqQ-Aw0thbprYAlpDmkqp__ibf64mELJtnPcsmL9DgV0TYYta5NZZyxqkBfzuhlMw5pgDhW60uyGRpFArYSiTSCHgS7oeIuBt-RFqMnRcAG9UBrBrgXrmksOxvn75Obz8HWOD397l0xWFKoa4um4j-fT4SP28XvvX_JczvJiJp8LafHpyuwXUQZIUw
ContentType Patent
DBID EVB
DatabaseName esp@cenet
DatabaseTitleList
Database_xml – sequence: 1
  dbid: EVB
  name: esp@cenet
  url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Chemistry
Sciences
ExternalDocumentID SG11201602962PA
GroupedDBID EVB
ID FETCH-epo_espacenet_SG11201602962PA3
IEDL.DBID EVB
IngestDate Fri Jul 19 12:50:05 EDT 2024
IsOpenAccess true
IsPeerReviewed false
IsScholarly false
Language English
LinkModel DirectLink
MergedId FETCHMERGED-epo_espacenet_SG11201602962PA3
Notes Application Number: SG20161102962P
OpenAccessLink https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160530&DB=EPODOC&CC=SG&NR=11201602962PA
ParticipantIDs epo_espacenet_SG11201602962PA
PublicationCentury 2000
PublicationDate 20160530
PublicationDateYYYYMMDD 2016-05-30
PublicationDate_xml – month: 05
  year: 2016
  text: 20160530
  day: 30
PublicationDecade 2010
PublicationYear 2016
RelatedCompanies VERTEX PHARMACEUTICALS INCORPORATED
RelatedCompanies_xml – name: VERTEX PHARMACEUTICALS INCORPORATED
Score 3.0319147
Snippet The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R 1 and R 2 is H or...
SourceID epo
SourceType Open Access Repository
SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title CO-CRYSTALS OF (S)-N-METHYL-8-(1-((2'-METHYL-[4,5'-BIPYRIMIDIN]-6-YL)AMINO)PROPAN-2-YL)QUINOLINE-4-CARBOXAMIDE AND DEUTERATED DERIVATIVES THEREOF AS DNA-PK INHIBITORS
URI https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160530&DB=EPODOC&locale=&CC=SG&NR=11201602962PA
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV1Lj9MwELZKQSw3KCB2oSiHqg-JEWmaVw_VyondxtA6IUmrVmi1SppE2sO2FQ3iH-3vZBK1PC5wG48tyw_N-LPnYUI6uV0YaW5kkFi6Cno-tiFJKyCnqoVVpMW4SGpvC2l6S_3T2lg3yP05FqbOE_qjTo6IErVFeS9rfX34_YjFat_K48f0Dln762k8Yd3T7XiI4Hykdpkz4YHPfLfrupNo1pXhBGFFVauNTS2gj8jjCklXqfb5yqkCUw5_nirT5-RJgB3uyhekke9a5MI9f77WIk8XJ5s3kifxO74kD64PbriJYjqPFH-q9KMBSFjw2NvMwYb-EPp9rXdmfNU_GD1wRLAJUUMxIW_AhM18QBdC-oMg9AMqQas4X5bImQvJQQeXho6_xjaMK1QyhfElIl6KCg7JUKxoLFY8UmKPhxyHQCOFSQrBZ0VITzgi9sPoFelMeex6gBO-_bXAt9Hsr-UZvSbN3X6XvyFKUVj5NsksLbMzPTO2tpUU5jDVEJTZo2w7vCTtf3Z19Z_6t-RZVarN8eo70iy_fc_beMqX6ft6b34C2s2d-Q
link.rule.ids 230,309,786,891,25594,76906
linkProvider European Patent Office
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV1Lb9swDBb6QrPb-sLWrasPRZoAJeo4duwcgkG2lFqtI7u2EyQYhsCObaCHpcGSYf9ov3O0kfRxaW8CKRCiBJKfRIki5CK3CiPNjQwSU1dBz7sWJGkJ5FS1MIu06BZJddtCdtyhfjs2xlvk1-YtTFUn9G9VHBEtaob2vqr89eL5EItVdyuX1-kDkh6_9-Meq693xy0E5221zuweD3zmO3XH6UU3dRn2EFaUXK3b0QK6TXbNskBviZ5GdvkwZfEyqvQ_kr0ABc5XB2Qrnx-SmrP5fO2Q7A_WOW9srs1veUT-OT444SSKqRcpfl9pRE2QMOCxO_HAgkYLGg3tckP4oV8Zl2CLYBKih2JC_oQOTLwmHQjpN4PQD6gEraTcD5HiCclBB4eGtj_GPowrVDKF8SEiXooODpuhGNFYjHikxC4POQ6BRgqTFII7RUhX2CL2w-iYXPR57LiACk-fJnga3byanvYJ2Zk_zvNPRCkKM58lmallVqZnxswyk6LTSjUEZVY7m7U-k7M3RZ2-wz8nNTceeFNU8e4L-VByqtS8-pXsrH7_yc8w4q_Sb9U6_QdozqDm
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=CO-CRYSTALS+OF+%28S%29-N-METHYL-8-%281-%28%282%27-METHYL-%5B4%2C5%27-BIPYRIMIDIN%5D-6-YL%29AMINO%29PROPAN-2-YL%29QUINOLINE-4-CARBOXAMIDE+AND+DEUTERATED+DERIVATIVES+THEREOF+AS+DNA-PK+INHIBITORS&rft.inventor=STROHMEIER%2C+MARK&rft.inventor=MUDUNURI%2C+PRAVEEN&rft.inventor=VAN+ALSTEN%2C+JOHN+GREGG&rft.inventor=KADIYALA%2C+IRINA+NIKOLAEVNA&rft.inventor=ZHANG%2C+YUEGANG&rft.inventor=WALDO%2C+MICHAEL&rft.inventor=STAVROPOULOS%2C+KATHY&rft.inventor=NTI-ADDAE%2C+KWAME%2C+WIREDU&rft.inventor=O%27NEIL%2C+SIMON%2C+ADAM&rft.inventor=SONG%2C+BIN&rft.inventor=NAVAMAL%2C+METTACHIT&rft.date=2016-05-30&rft.externalDBID=A&rft.externalDocID=SG11201602962PA