CELLS FOR PRODUCING RECOMBINANT IDURONATE-2-SULFATASE
The present invention provides, among other things, methods and compositions for production of recombinant I2S protein with improved potency and activity using cells co-express I2S and FGE protein. In some embodiments, cells according to the present invention are engineered to simultaneously over-ex...
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Format | Patent |
Language | English |
Published |
27.02.2015
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Online Access | Get full text |
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Abstract | The present invention provides, among other things, methods and compositions for production of recombinant I2S protein with improved potency and activity using cells co-express I2S and FGE protein. In some embodiments, cells according to the present invention are engineered to simultaneously over-express recombinant I2S and FGE proteins. Cells according to the invention are adaptable to various cell culture conditions. In some embodiments, cells of the present invention adaptable to a large-scale suspension serum-free culture. |
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AbstractList | The present invention provides, among other things, methods and compositions for production of recombinant I2S protein with improved potency and activity using cells co-express I2S and FGE protein. In some embodiments, cells according to the present invention are engineered to simultaneously over-express recombinant I2S and FGE proteins. Cells according to the invention are adaptable to various cell culture conditions. In some embodiments, cells of the present invention adaptable to a large-scale suspension serum-free culture. |
Author | BOLDOG, FERENC HEARTLEIN, MICHAEL |
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RelatedCompanies | SHIRE HUMAN GENETIC THERAPIES, INC |
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Snippet | The present invention provides, among other things, methods and compositions for production of recombinant I2S protein with improved potency and activity using... |
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SubjectTerms | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
Title | CELLS FOR PRODUCING RECOMBINANT IDURONATE-2-SULFATASE |
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