Enrichment And Identification Of Fetal Cells In Maternal Blood And Ligands For Such Use

The present invention relates to enrichment and/or identification of fetal cells of a maternal blood sample using fetal cell specific ligands and/or fetal cell specific hybridization probes wherein the ligand or probes are directed to an endothelial/mesenchymal marker, e.g. CD105, CD146 or CD141, in...

Full description

Saved in:
Bibliographic Details
Main Authors ECKELT, ANDREAS, HATT, LOTTE, SINGH, RIPUDAMEN, KØLVRAA, STEEN, BRINCH, MARIE, CHRISTENSEN, BRITTA
Format Patent
LanguageEnglish
Published 30.12.2015
Online AccessGet full text

Cover

Loading…
Abstract The present invention relates to enrichment and/or identification of fetal cells of a maternal blood sample using fetal cell specific ligands and/or fetal cell specific hybridization probes wherein the ligand or probes are directed to an endothelial/mesenchymal marker, e.g. CD105, CD146 or CD141, in a first round of enrichment and the ligand or probes, in a second round of enrichment, are directed to an epithelial marker, e.g. a cytokeratin, such as CK7, CK8, CK18 or CK19. Enriched or identified fetal cells may be subjected to steps of detection or diagnosis, wherefore the present invention enables non-invasive 5 prenatal diagnostics.
AbstractList The present invention relates to enrichment and/or identification of fetal cells of a maternal blood sample using fetal cell specific ligands and/or fetal cell specific hybridization probes wherein the ligand or probes are directed to an endothelial/mesenchymal marker, e.g. CD105, CD146 or CD141, in a first round of enrichment and the ligand or probes, in a second round of enrichment, are directed to an epithelial marker, e.g. a cytokeratin, such as CK7, CK8, CK18 or CK19. Enriched or identified fetal cells may be subjected to steps of detection or diagnosis, wherefore the present invention enables non-invasive 5 prenatal diagnostics.
Author BRINCH, MARIE
CHRISTENSEN, BRITTA
HATT, LOTTE
ECKELT, ANDREAS
SINGH, RIPUDAMEN
KØLVRAA, STEEN
Author_xml – fullname: ECKELT, ANDREAS
– fullname: HATT, LOTTE
– fullname: SINGH, RIPUDAMEN
– fullname: KØLVRAA, STEEN
– fullname: BRINCH, MARIE
– fullname: CHRISTENSEN, BRITTA
BookMark eNqNi70KwjAURjPo4N873MFVSFscHGtptKA41J-xhOTGBuJNSeL7W8QHcPoOh_PN2YQ84Yw9agpW9S-kBCVpaPRI1lglk_UEFwMCk3RQoXMRGoKzTBhoNHvnvf5-TvYpSUcQPkD7Vj3cIi7Z1EgXcfXbBVuL-lodNzj4DuMgFRKmrj1kPOfZlu_ygt_L4s_sA_bqOwM
ContentType Patent
DBID EVB
DatabaseName esp@cenet
DatabaseTitleList
Database_xml – sequence: 1
  dbid: EVB
  name: esp@cenet
  url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Chemistry
Sciences
ExternalDocumentID SG10201509230VA
GroupedDBID EVB
ID FETCH-epo_espacenet_SG10201509230VA3
IEDL.DBID EVB
IngestDate Fri Jul 19 14:57:10 EDT 2024
IsOpenAccess true
IsPeerReviewed false
IsScholarly false
Language English
LinkModel DirectLink
MergedId FETCHMERGED-epo_espacenet_SG10201509230VA3
Notes Application Number: SG20151009230V
OpenAccessLink https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20151230&DB=EPODOC&CC=SG&NR=10201509230VA
ParticipantIDs epo_espacenet_SG10201509230VA
PublicationCentury 2000
PublicationDate 20151230
PublicationDateYYYYMMDD 2015-12-30
PublicationDate_xml – month: 12
  year: 2015
  text: 20151230
  day: 30
PublicationDecade 2010
PublicationYear 2015
RelatedCompanies ARCEDI BIOTECH APS
RelatedCompanies_xml – name: ARCEDI BIOTECH APS
Score 3.0207398
Snippet The present invention relates to enrichment and/or identification of fetal cells of a maternal blood sample using fetal cell specific ligands and/or fetal cell...
SourceID epo
SourceType Open Access Repository
Title Enrichment And Identification Of Fetal Cells In Maternal Blood And Ligands For Such Use
URI https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20151230&DB=EPODOC&locale=&CC=SG&NR=10201509230VA
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV1bT8IwFD5BNOqbogYvmD6QvS3WbYzxQAzsAhq5RC7yRijrhAQLYSP-fU_L8PKib-uaNmdNTs932vN9AyjaZoigPuJ6KTJkgsKp7lgW0xGLTCrMsBidSHJyq203B9bTqDTKwPuOC6N0Qj-UOCJ61BT9PVH79er7EMtTtZXxHZvjq-VD0K96Wpody_BlUs2rV_1ux-u4mutWew2t_YJYV_ZShDN0WNuDfYmkpdS-P6xLYsrqZ1QJTuCgixOK5BQyXOTgyN39fC0Hh630zhsfU_eLz-DVF7htzeSBHqmJkGxZtlFqMelEJECrF8Tli0VMHgVpTbYaz6Qu69PVmOf5m2T3kmC5Jr3NdEYGMT-HYuD33aaOFo6_VmTca_z6HvMCsmIpeB5IaDgY9SqmaZWZZdqUlakRcsxzqTO1Def-Egp_TnX1T_81HMuWkjqkN5BN1htewLCcsFu1mJ8wA464
link.rule.ids 230,309,786,891,25594,76903
linkProvider European Patent Office
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV3dT8IwEL8gGvFNUeMX2geyt8W6jTEeiIGNAcqAyIe8EcY6IcFC2Ij_vtcy_HjRt6aXNtcm17tfe78rQN7UAwzqQ6YWQk0AFEZVyzB8FWORScnXDJ9OBDnZa5uNgfE0KoxS8L7jwsg6oR-yOCJa1BTtPZbn9er7EsuRuZXRvT_HruWj2y87SoKOhfvSqeJUy7Vux-nYim2Xe3Wl_YKxrpBSDGfosLIH-0VEhRItDauCmLL66VXcYzjo4oQ8PoEU41nI2LvP17Jw6CVv3thMzC86hdcax2NrJi70SIUHZMuyDRONSSckLmq9IDZbLCLS5MSbbGs8k6rIT5djWvM3we4l7nJNepvpjAwidgZ5t9a3GypqOP7akXGv_ms9-jmk-ZKzCyCBZqHXK-m6UfQN3aR-kWoBQ5xLrampWQ-XkPtzqqt_5HeQafS91rjVbD9fw5GQyLKH9AbS8XrDcuiiY_9WbuwnAgCRog
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=Enrichment+And+Identification+Of+Fetal+Cells+In+Maternal+Blood+And+Ligands+For+Such+Use&rft.inventor=ECKELT%2C+ANDREAS&rft.inventor=HATT%2C+LOTTE&rft.inventor=SINGH%2C+RIPUDAMEN&rft.inventor=K%C3%98LVRAA%2C+STEEN&rft.inventor=BRINCH%2C+MARIE&rft.inventor=CHRISTENSEN%2C+BRITTA&rft.date=2015-12-30&rft.externalDBID=A&rft.externalDocID=SG10201509230VA