DERIVATIVE OF THE CLASS OF N-GLYCOSIDES INDOLO[2,3-A]PYRROLO[3,4-C]CARBAZOLE-5,7-DIONE - N-{12-(β-D-XYLOPYRANOSYL)-5,7-DIOXO-INDOLO[2,3-A]PYRROLO[3,4-C]CARBAZOL-6-YL} PYRIDINE-2-CARBOXAMIDE, WHICH HAS CYTOTOXIC AND ANTITUMOR ACTIVITY

FIELD: pharmaceuticals.SUBSTANCE: invention relates to use of the indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione N-glycoside derivative - N-{12-(β-D-xylopyranosyl)-5,7-dioxo-indolo[2,3-a]pyrrolo[3,4-c]carbazol-6-yl}pyridine-2-carboxamide as a compound having antitumor activity for the treatment of m...

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Main Authors Golubeva Irina Sergeevna, Moiseeva Natalya Ivanovna, Ektova Lidiya Vladimirovna, Eremina Vera Aleksandrovna, Yavorskaya Nadezhda Petrovna
Format Patent
LanguageEnglish
Russian
Published 25.09.2018
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Abstract FIELD: pharmaceuticals.SUBSTANCE: invention relates to use of the indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione N-glycoside derivative - N-{12-(β-D-xylopyranosyl)-5,7-dioxo-indolo[2,3-a]pyrrolo[3,4-c]carbazol-6-yl}pyridine-2-carboxamide as a compound having antitumor activity for the treatment of mice with adenocarcinoma of the mammary gland Ca 755, epidermoid carcinoma of Lewis lungs, melanoma B16, cervical cancer, adenocarcinoma of the colon ACTOL, Ehrlich tumor in therapeutic doses.EFFECT: new application of a known biologically active compound has been proposed.1 cl, 3 tbl, 1 ex Изобретение относится к применению производного N-гликозида индоло[2,3-а]пирроло[3,4-с]карбазол-5,7-диона - N-{12-(β-D-ксилопиранозил)-5,7-диоксо-индоло[2,3-а]пирроло[3,4-с]карбазол-6-ил}пиридин-2-карбоксамида в качестве соединения, обладающего противоопухолевой активностью, для лечения мышей с аденокарциномой молочной железы Са 755, эпидермоидной карциномой легких Льюиса, меланомой В16, раком шейки матки, аденокарциономой толстой кишки АКАТОЛ, опухолью Эрлиха в терапевтических дозах. Предложено новое применение известного биологически активного соединения. 3 табл., 1 пр.
AbstractList FIELD: pharmaceuticals.SUBSTANCE: invention relates to use of the indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione N-glycoside derivative - N-{12-(β-D-xylopyranosyl)-5,7-dioxo-indolo[2,3-a]pyrrolo[3,4-c]carbazol-6-yl}pyridine-2-carboxamide as a compound having antitumor activity for the treatment of mice with adenocarcinoma of the mammary gland Ca 755, epidermoid carcinoma of Lewis lungs, melanoma B16, cervical cancer, adenocarcinoma of the colon ACTOL, Ehrlich tumor in therapeutic doses.EFFECT: new application of a known biologically active compound has been proposed.1 cl, 3 tbl, 1 ex Изобретение относится к применению производного N-гликозида индоло[2,3-а]пирроло[3,4-с]карбазол-5,7-диона - N-{12-(β-D-ксилопиранозил)-5,7-диоксо-индоло[2,3-а]пирроло[3,4-с]карбазол-6-ил}пиридин-2-карбоксамида в качестве соединения, обладающего противоопухолевой активностью, для лечения мышей с аденокарциномой молочной железы Са 755, эпидермоидной карциномой легких Льюиса, меланомой В16, раком шейки матки, аденокарциономой толстой кишки АКАТОЛ, опухолью Эрлиха в терапевтических дозах. Предложено новое применение известного биологически активного соединения. 3 табл., 1 пр.
Author Yavorskaya Nadezhda Petrovna
Eremina Vera Aleksandrovna
Moiseeva Natalya Ivanovna
Golubeva Irina Sergeevna
Ektova Lidiya Vladimirovna
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– fullname: Eremina Vera Aleksandrovna
– fullname: Yavorskaya Nadezhda Petrovna
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DocumentTitleAlternate Производное класса N-гликозидов индоло[2,3-а]пирроло[3,4-с]карбазол-5,7-дионов - N-{ 12-(β-D-ксилопиранозил)-5,7-диоксо-индоло[2,3-а]пирроло[3,4-с] карбазол-6-ил} пиридин-2-карбоксамид, обладающее цитотоксической и противоопухолевой активностью
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RelatedCompanies Federalnoe gosudarstvennoe byudzhetnoe uchrezhdenie "Natsionalnyj meditsinskij issledovatelskij tsentr onkologii imeni N.N. Blokhina" Ministerstva zdravookhraneniya Rossijskoj Federatsii (FGBU "NMITS onkologii im. N.N. Blokhina" Minzdrava Rossii)
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Snippet FIELD: pharmaceuticals.SUBSTANCE: invention relates to use of the indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione N-glycoside derivative -...
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DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Title DERIVATIVE OF THE CLASS OF N-GLYCOSIDES INDOLO[2,3-A]PYRROLO[3,4-C]CARBAZOLE-5,7-DIONE - N-{12-(β-D-XYLOPYRANOSYL)-5,7-DIOXO-INDOLO[2,3-A]PYRROLO[3,4-C]CARBAZOL-6-YL} PYRIDINE-2-CARBOXAMIDE, WHICH HAS CYTOTOXIC AND ANTITUMOR ACTIVITY
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