SUBSTITUTED PYRROLO[4,3-b]INDOLES, COMBINATORY AND FOCUSED LIBRARY, PHARMACEUTICAL COMPOSITION, METHODS FOR THEIR PREPARING AND USING

• Main Authors: IVASHCHENKO ALEKSANDR VASIL'EVICH, KHVAT ALEKSANDR VIKTOROVICH, MALJARCHUK SERGEJ VIKTOROVICH, MIT'KIN OLEG DMITRIEVICH, SAVCHUK NIKOLAJ FILIPPOVICH, TKACHENKO SERGEJ EVGEN'EVICH, FROLOV EVGENIJ BORISOVICH, OKUN' IL'JA MATUSOVICH, IVASHCHENKO ANDREJ ALEKSANDROVICH
• Format: Patent
• Language: English; Russian
• Published: 27.03.2008
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

FIELD: organic chemistry, medicine, neurology, pharmacy. ^ SUBSTANCE: invention relates to novel hydrogenated pyrrolo[4,3-b]indoles of the general formula (1): , their racemates, optical isomers, geometric isomers, pharmaceutically acceptable salts and/or hydrates that can be used, for example, in treatment and prophylaxis of different neurodegenerative diseases, such as Alzheimer's syndrome. In the general formula (1): a dotted line with accompanying unbroken line represents ordinary or double bond; R1 and R2 represent independently of one another substitutes of amino group chosen from hydrogen atom, possibly substituted (C1-C6)-alkyl substituted possibly with aryl, possibly substituted phenyl, possibly substituted carbonylamino or thiocarbonylamino group, substituted acyl, possibly substituted aryl sulfonate wherein substituted in indicated R1 and R2 are chosen from (C1-C6)-alkyl, halogen atoms, nitro, carboxy, alkoxy group, aryl; R1 n represents one or some similar or different substituted of cyclic system chosen from hydrogen atom, alkyl, aryl, cyano group, halogen atom, 5-6-membered nitrogen-containing heteroaryl. Also, invention relates to methods for synthesis of these compounds, pharmaceutical compositions and their using, and to using compounds in libraries with their using. ^ EFFECT: valuable medicinal properties of compounds and pharmaceutical compositions, improved methods of synthesis. ^ 20 cl, 2 tbl, 12 ex