PHOTOSENSIBILIZING AGENT, LIPOSOMAL FORMULATION OF PHOTOSENSIBILIZING AGENT AND METHOD FOR CARRYING OUT PHOTODYNAMIC THERAPY

• Main Authors: BORISOVA L.M, LOSHCHENOV V.B, MEEROVICH G.A, DERKACHEVA V.M, SMIRNOVA Z.S, POLOZKOVA A.P, LUK'JANETS E.A, MEEROVICH I.G, OBOROTOVA N.A, BARYSHNIKOV A.JU, GERASIMOVA G.K, KOKAREVA V.I, STRATONNIKOV A.A, VOROZHTSOV G.N, DAVYDOV M.I, KUBASOVA I.JU, LUZHKOV JU.M
• Format: Patent
• Language: English; Russian
• Published: 10.08.2005
• Edition: 7
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

FIELD: organic chemistry, medicine. ^ SUBSTANCE: invention relates to a photosensibilizing compound representing phenylthio-substituted derivative of phthalocyanine of the general formula (I): wherein R means hydrogen atom (H), t-C4H9; M means HH, AlOH, Zn. Also, invention relates to its liposomal formulation representing the composition of mixture of lipids (lecithin, cholesterol, cardiolipin) and a photosensibilizing agent, and to a method for carrying out the photodynamic therapy using this formulation. Photosensibilizing agents show high elimination rate from normal tissues, provide the deep therapeutic effect on tumor tissues, non-toxic properties and perspective for their using in oncology and other branches of medicine. ^ EFFECT: valuable medicinal properties of compound. ^ 4 cl, 3 dwg, 9 ex