RECOMBINANT ATTENUATED STRAIN OF BACTERIUM SALMONELLA TYPHIMURIUM T10/PKHBC AS PRODUCER OF HEPATITIS B VIRUS CORE ANTIGEN

FIELD: biotechnology, genetic engineering. SUBSTANCE: invention proposes the novel recombinant attenuated strain of bacterium Salmonella tryphimurium T10/pKHBc that is obtained by method of genetic transformation of the strain Salmonella typhimurium T10 with plasmid pKHBc. The strain provides consti...

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Bibliographic Details
Main Authors IGNAT'EV G.M, VOROB'EV A.A, KARPENKO L.I, VEREMEJKO T.A, IL'ICHEV A.A, BOJCHENKO M.N
Format Patent
LanguageEnglish
Published 20.11.2003
Edition7
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES USING MICROORGANISMS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:FIELD: biotechnology, genetic engineering. SUBSTANCE: invention proposes the novel recombinant attenuated strain of bacterium Salmonella tryphimurium T10/pKHBc that is obtained by method of genetic transformation of the strain Salmonella typhimurium T10 with plasmid pKHBc. The strain provides constitutive synthesis of HbcAg (core antigen of hepatitis B virus). After administration of the strain to laboratory animals it causes induction of specific anti-VGV antibodies and specific cellular response. The novel strain can be used for construction of live vaccine against hepatitis B. EFFECT: valuable medicinal properties of strain and antigen. 2 dwg, 1 tbl, 2 ex
Bibliography:Application Number: RU20020105085