1-((3S,4R)-4-(3-FLUOROPHENYL)-1-(2-METHOXYETHYL)PYRROLIDIN-3-YL)-3-(4-METHYL-3-(2-METHYLPYRIMIDIN-5-YL)-1-PHENYL-1H-PYRAZOL-5-YL)UREA AS A TRKA KINASE INHIBITOR
Provided is Compound 1or a pharmaceutically acceptable salt thereof, which is an inhibitor of TrkA kinase and is useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation and inflammatory diseases, neurodegenerative diseases, certain inf...
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Main Authors | , , , , , |
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Format | Patent |
Language | English Serbian |
Published |
31.10.2019
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Abstract | Provided is Compound 1or a pharmaceutically acceptable salt thereof, which is an inhibitor of TrkA kinase and is useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation and inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis, pelvic pain syndrome, diseases related to an imbalance of the regulation of bone remodeling, and diseases resulting from Connective Tissue Growth Factor aberrant signaling. |
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AbstractList | Provided is Compound 1or a pharmaceutically acceptable salt thereof, which is an inhibitor of TrkA kinase and is useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation and inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis, pelvic pain syndrome, diseases related to an imbalance of the regulation of bone remodeling, and diseases resulting from Connective Tissue Growth Factor aberrant signaling. |
Author | LIU, WEIDONG ALLEN, SHELLEY BAER, BRIAN ANDREWS, STEVEN, W WATSON, DANIEL, JOHN CRANE, ZACKARY |
Author_xml | – fullname: WATSON, DANIEL, JOHN – fullname: LIU, WEIDONG – fullname: CRANE, ZACKARY – fullname: BAER, BRIAN – fullname: ALLEN, SHELLEY – fullname: ANDREWS, STEVEN, W |
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DocumentTitleAlternate | 1-((3S,4R)-4-(3-FLUOROFENIL)-1-(2-METOKSIETIL)PIROLIDIN-3-IL)-3-(4-METIL-3-(2-METILPIRIMIDIN-5-IL)-1-FENIL-1H-PIRAZOL-5-IL)UREA KAO INHIBITOR TRKA KINAZE |
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Notes | Application Number: RS2019P001168 |
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RelatedCompanies | ARRAY BIOPHARMA, INC |
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Snippet | Provided is Compound 1or a pharmaceutically acceptable salt thereof, which is an inhibitor of TrkA kinase and is useful in the treatment of diseases which can... |
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SubjectTerms | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
Title | 1-((3S,4R)-4-(3-FLUOROPHENYL)-1-(2-METHOXYETHYL)PYRROLIDIN-3-YL)-3-(4-METHYL-3-(2-METHYLPYRIMIDIN-5-YL)-1-PHENYL-1H-PYRAZOL-5-YL)UREA AS A TRKA KINASE INHIBITOR |
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