TRIAZINE COMPOUNDS AS P13 KINASE AND MTOR INHIBITORS
TRIAZINE COMPOUNDS AS PI3 KINASE AND MTOR INHIBITORS Compounds of formula I wherein: R 1 is and R 2 , R 4 , and R 6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase an...
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Main Authors | , , , , , , , , , , , , , |
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Format | Patent |
Language | English Serbian |
Published |
28.06.2019
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Subjects | |
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Abstract | TRIAZINE COMPOUNDS AS PI3 KINASE AND MTOR INHIBITORS Compounds of formula I
wherein:
R 1 is
and R 2 , R 4 , and R 6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed. |
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AbstractList | TRIAZINE COMPOUNDS AS PI3 KINASE AND MTOR INHIBITORS Compounds of formula I
wherein:
R 1 is
and R 2 , R 4 , and R 6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed. |
Author | DEHNHARDT, CHRISTOPH, M CHEN, ZECHENG AYRAL-KALOUSTIAN, SEMIRAMIS MANSOUR, TAREK, S SHI, MENGXIAO DELOS SANTOS, EFREN, GUILLERMO VENKATESAN, ARANAPAKAM, M DOS SANTOS, OSVALDO KAPLAN, JOSHUA, AARON CURRAN, KEVIN, J GOPALSAMY, ARIAMALA RICHARD, DAVID, J ZASK, ARIE VERHEIJEN, JEROEN, C |
Author_xml | – fullname: VENKATESAN, ARANAPAKAM, M – fullname: AYRAL-KALOUSTIAN, SEMIRAMIS – fullname: SHI, MENGXIAO – fullname: DELOS SANTOS, EFREN, GUILLERMO – fullname: GOPALSAMY, ARIAMALA – fullname: CURRAN, KEVIN, J – fullname: DOS SANTOS, OSVALDO – fullname: MANSOUR, TAREK, S – fullname: DEHNHARDT, CHRISTOPH, M – fullname: KAPLAN, JOSHUA, AARON – fullname: ZASK, ARIE – fullname: CHEN, ZECHENG – fullname: VERHEIJEN, JEROEN, C – fullname: RICHARD, DAVID, J |
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DocumentTitleAlternate | JEDINJENJA TRIAZINA KAO INHIBITORI PI3 KINAZE I MTOR |
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Notes | Application Number: RS2019P000552 |
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Snippet | TRIAZINE COMPOUNDS AS PI3 KINASE AND MTOR INHIBITORS Compounds of formula I
wherein:
R 1 is
and R 2 , R 4 , and R 6-9 are defined herein, and pharmaceutically... |
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SourceType | Open Access Repository |
SubjectTerms | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
Title | TRIAZINE COMPOUNDS AS P13 KINASE AND MTOR INHIBITORS |
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