RETINOID-LIPOSOMES FOR ENHANCING MODULATION OF HSP47 EXPRESSION

• Main Authors: WITTE, RICHARD, P, AKOPIAN, VIOLETTA, MINOMI, KENJIRO, KNOPOV, VICTOR, AHMADIAN, MOHAMMAD, AVKIN-NACHUM, SHARON, TANAKA, YASUNOBU, PAYNE, JOSEPH, E, FEINSTEIN, ELENA, METT, IGOR, KALINSKI, HAGAR, LUI, YUN, PERELMAN, LOREN, A, YING, WENBIN, NIITSU, YOSHIRO
• Format: Patent
• Language: English; Serbian
• Published: 31.12.2018
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

What is described are pharmaceutical compositions comprising a double-stranded nuclei acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1_2 (SEQ ID NOS: 60 and 127), SERPTNH1-45a (SEQ ID NOS: 98 and 165), and SERPTNH1_51 (SEQ ID NOS: 101 and 168), and drug carrier comprising a mixture of a retinoid and a lipid vesicle, and methods of using these pharmaceutical compositions to treat a disease associated with hsp47 expression, including fibrosis.