HETEROBICYCLOARYL RORC2 INHIBITORS AND METHODS OF USE THEREOF

The present invention provides compounds, pharmaceutical compositions, methods of inhibiting RORy activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such compounds and pharmaceutical compositions.

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Main Authors JONES, PETER, THORARENSEN, ATLI, WENNERSTÅL, GÖRAN MATTIAS, ZAPF, CHRISTOPH WOLFGANG, MEYERS, MARVIN JAY, MENTE, SCOT RICHARD, SCHNUTE, MARK EDWARD, BLINN, JAMES ROBERT, FLICK, ANDREW CHRISTOPHER, XING, LI, KURUMBAIL, RAVI G, ZAMARATSKI, EDOUARD, KAILA, NEELU, KIEFER, JAMES RICHARD JR
Format Patent
LanguageEnglish
Serbian
Published 30.11.2018
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Abstract The present invention provides compounds, pharmaceutical compositions, methods of inhibiting RORy activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such compounds and pharmaceutical compositions.
AbstractList The present invention provides compounds, pharmaceutical compositions, methods of inhibiting RORy activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such compounds and pharmaceutical compositions.
Author ZAMARATSKI, EDOUARD
WENNERSTÅL, GÖRAN MATTIAS
BLINN, JAMES ROBERT
MENTE, SCOT RICHARD
SCHNUTE, MARK EDWARD
ZAPF, CHRISTOPH WOLFGANG
FLICK, ANDREW CHRISTOPHER
KURUMBAIL, RAVI G
JONES, PETER
KIEFER, JAMES RICHARD JR
MEYERS, MARVIN JAY
THORARENSEN, ATLI
XING, LI
KAILA, NEELU
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– fullname: MEYERS, MARVIN JAY
– fullname: MENTE, SCOT RICHARD
– fullname: SCHNUTE, MARK EDWARD
– fullname: BLINN, JAMES ROBERT
– fullname: FLICK, ANDREW CHRISTOPHER
– fullname: XING, LI
– fullname: KURUMBAIL, RAVI G
– fullname: ZAMARATSKI, EDOUARD
– fullname: KAILA, NEELU
– fullname: KIEFER, JAMES RICHARD JR
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Snippet The present invention provides compounds, pharmaceutical compositions, methods of inhibiting RORy activity and/or reducing the amount of IL-17 in a subject,...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title HETEROBICYCLOARYL RORC2 INHIBITORS AND METHODS OF USE THEREOF
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