PROCESS FOR THE PREPARATION OF LEUKOTRIENE ANTAGONISTS

• Main Authors: VOLANTE RALPH P, BERGAN JAMES J, BHUPATHY MAHADEVAN, MCNAMARA JAMES M, SIDLER DANIEL R
• Format: Patent
• Language: English; Romanian
• Published: 27.02.2004
• Edition: 7
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a process for the preparation of leukotriene antagonists corresponding to the formula I and the sodium salts thereof, wherein HET is 7-chloroquinolin-2-yl or 6,7-difluoroquinolin-2-yl, process which supposes : reacting the dilithium dianion of 1-(mercapto-methyl)cyclopropane...