REFORMATTED, HUMAN ANTIBODY AND GENE WHICH CODIFY IT THEREOF

• Main Author: VERHOEYEN MARTINE ELISA
• Format: Patent
• Language: English; Romanian
• Published: 30.11.1995
• Edition: 6
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

A reshaped human antibody or reshaped human antibody fragment having specificity for human placental alkaline phosphatase (PLAP) is produced by transferring the complementarity determining regions (CDRs) from a murine anti-PLAP hybridoma cell line H17E2 into a human antibody variable region framework. The reshaped molecule can be used in the treatment or diagnosis of cancer