PROCESSO PARA A PRODUCAO DE PIRIMIDINO-2-ACETATOS

• Main Authors: GERHARD STUCKY, YVES BESSARD
• Format: Patent
• Language: Portuguese
• Published: 28.11.2003
• Edition: 7
• Subjects: APPARATUS THEREFOR; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; THEIR RELEVANT APPARATUS; TRANSPORTING

Production of pyrimidine-2-acetic acid esters of formula (I) comprises reacting a 2-halomethylpyrimidine of formula (II) with carbon monoxide and an alcohol of formula ROH (III) in the presence of a palladium-phosphine complex catalyst and a base. R = 1-6 alkyl, 3-6C cycloalkyl, aryl or aralkyl; R -...