IMPROVED PROCESS FOR THE PREPARATION OF ENCAINIDE

• Main Author: GARY D. MADDING
• Format: Patent
• Language: English
• Published: 01.01.1983
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HOROLOGY; MECHANICAL PARTS OF CLOCKS OR WATCHES IN GENERAL; MECHANICALLY-DRIVEN CLOCKS OR WATCHES; METALLURGY; ORGANIC CHEMISTRY; PHYSICS; TIME PIECES USING THE POSITION OF THE SUN, MOON OR STARS

An improved process for the preparation of 4-methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide has been developed. The process comprises essentially three steps starting with methyl anthranilate and 2-picoline and features a novel low-pressure hydrogenation sequence.