SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS

Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by alle...

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Main Authors MARZENA MAZUR, ROBERT KORALEWSKI, BARTLOMIEJ BOREK, ELZBIETA PLUTA, MICHAL C. PIOTROWICZ, JACEK P. OLCZAK, MICHAL L. KOWALSKI, ADAM A. GOLEBIOWSKI, WOJCIECH J. CZESTKOWSKI, AGNIESZKA BARTOSZEWICZ, SYLWIA OLEJNICZAK
Format Patent
LanguageEnglish
Portuguese
Published 01.04.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.
AbstractList Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.
Author SYLWIA OLEJNICZAK
BARTLOMIEJ BOREK
ADAM A. GOLEBIOWSKI
ELZBIETA PLUTA
JACEK P. OLCZAK
AGNIESZKA BARTOSZEWICZ
WOJCIECH J. CZESTKOWSKI
MICHAL L. KOWALSKI
MICHAL C. PIOTROWICZ
MARZENA MAZUR
ROBERT KORALEWSKI
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– fullname: MICHAL L. KOWALSKI
– fullname: ADAM A. GOLEBIOWSKI
– fullname: WOJCIECH J. CZESTKOWSKI
– fullname: AGNIESZKA BARTOSZEWICZ
– fullname: SYLWIA OLEJNICZAK
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DocumentTitleAlternate AMINO TRIAZÓIS SUBSTITUÍDOS ÚTEIS COMO INIBIDORES DE QUITINASE HUMANA
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Snippet Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS
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