ANTI-S100A7 ANTIBODIES FOR THE TREATMENT AND DIAGNOSIS OF CANCER

• Main Authors: FRANCESC MITJANS PRAT, ROSA Mª HERVAS VILLEGAS, JOSÉ LUIS HERNÁNDEZ MÍGUEZ, SHEILA DAKHEL PLAZA, JOSEP MARIA MARTÍNEZ ESCOLÀ, MARC MASA ÁLVAREZ, ANTONIO COLL MANZANO, LOURDES TATIANA ROQUE NAVARRO, LAURA PADILLA GARCÍA, RAMON MESSEGUER PEYPOCH, LAURA BARBERÀ FERRANDO, CARME CALVIS CALPE, JAUME ADAN PLANA, MANUEL RIVAS CAÑAS
• Format: Patent
• Language: English; Portuguese
• Published: 19.09.2017
• Subjects: CHEMISTRY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; TESTING

The present invention relates to the use of antibodies against S100A7 protein for the prevention and/or treatment of cancer or a disease associated to an undesired angiogenesis or a disease associated with inflammation; and to methods and kits for diagnosing and determining the prognostic of said diseases in vitro and in vivo by means of detecting levels of S100A7 in a biofluid, preferably with an antibody. The invention also relates to specific anti-S100A7 monoclonal antibodies, hybridoma cell lines producing them and method for obtaining them, as well as pharmaceutical compositions and conjugates containing them.