DELIVERY SYSTEM FOR SUSTAINED RELEASE OF A CALCIUM-CHANNEL BLOCKING AGENT

A delivery system for sustained release of a calcium-channel blocking agent is adapted for introduction in the cerebrospinal fluid of a subject. The delivery system comprises a solid dispersion product of a calcium-channel blocking agent in a mixture of a (i) first poly(lactide-co-glycolide) having...

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Main Authors JÖRG BREITENBACH, PETER HÖLIG, STEFFEN BOSSMANN, BERND LIEPOLD, BENEDIKT STEITZ, DIDIER LEFEBVRE
Format Patent
LanguageEnglish
Portuguese
Published 14.11.2018
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Abstract A delivery system for sustained release of a calcium-channel blocking agent is adapted for introduction in the cerebrospinal fluid of a subject. The delivery system comprises a solid dispersion product of a calcium-channel blocking agent in a mixture of a (i) first poly(lactide-co-glycolide) having a molecular weight distribution centered around a first number average molecular weight Mn1 and a (ii) second poly(lactide-co-glycolide) having a molecular weight distribution centered around a second number average molecular weight Mn2, wherein Mn1 is in the range of from 2000 to 3000 g/mol and the ratio of Mn1/Mn2 is from 1.8 to 3.5. The delivery system is deposited in the vicinity of or adjacent to a blood vessel showing vasospasm or suspected of developing vasospasm.
AbstractList A delivery system for sustained release of a calcium-channel blocking agent is adapted for introduction in the cerebrospinal fluid of a subject. The delivery system comprises a solid dispersion product of a calcium-channel blocking agent in a mixture of a (i) first poly(lactide-co-glycolide) having a molecular weight distribution centered around a first number average molecular weight Mn1 and a (ii) second poly(lactide-co-glycolide) having a molecular weight distribution centered around a second number average molecular weight Mn2, wherein Mn1 is in the range of from 2000 to 3000 g/mol and the ratio of Mn1/Mn2 is from 1.8 to 3.5. The delivery system is deposited in the vicinity of or adjacent to a blood vessel showing vasospasm or suspected of developing vasospasm.
Author DIDIER LEFEBVRE
BENEDIKT STEITZ
PETER HÖLIG
STEFFEN BOSSMANN
JÖRG BREITENBACH
BERND LIEPOLD
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– fullname: DIDIER LEFEBVRE
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DocumentTitleAlternate SISTEMA DE ADMINISTRAÇÃO PARA A LIBERTAÇÃO SUSTENTADA DE UM BLOQUEADOR DOS CANAIS DE CÁLCIO
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Snippet A delivery system for sustained release of a calcium-channel blocking agent is adapted for introduction in the cerebrospinal fluid of a subject. The delivery...
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HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title DELIVERY SYSTEM FOR SUSTAINED RELEASE OF A CALCIUM-CHANNEL BLOCKING AGENT
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