SPIROCYCLIC AMILORIDE ANALOGUES AS ENAC BLOCKERS
A compound of Formula I in free or salt or solvate form, where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and R 11 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. In particular, airwa...
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| Main Authors | , , , , , , , , , , , |
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| Format | Patent |
| Language | English Portuguese |
| Published |
03.01.2018
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| Subjects | |
| Online Access | Get full text |
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| Abstract | A compound of Formula I
in free or salt or solvate form, where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and R 11 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. In particular, airway diseases like COPD and cystic fibrosis are treatable, but also inflammatory and allergic diseases. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described. |
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| AbstractList | A compound of Formula I
in free or salt or solvate form, where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and R 11 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. In particular, airway diseases like COPD and cystic fibrosis are treatable, but also inflammatory and allergic diseases. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described. |
| Author | PAUL OAKLEY NICHOLA SMITH PETER GEDECK THOMAS ANTHONY HUNT GURDIP BHALAY GRAHAM CHARLES BLOOMFIELD CATHERINE HOWSHAM LEE EDWARDS ANDREW DUNSTAN EMMA BUDD STEPHEN PAUL COLLINGWOOD PETER HUNT |
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| DocumentTitleAlternate | ANÁLOGOS DA AMILORIDA ESPIROCÍCLICOS COMO BLOQUEADORES DE ENAC |
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| Notes | Application Number: PT20110184004T |
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| RelatedCompanies | NOVARTIS AG |
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| Snippet | A compound of Formula I
in free or salt or solvate form, where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and R 11 have the meanings as... |
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| SubjectTerms | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| Title | SPIROCYCLIC AMILORIDE ANALOGUES AS ENAC BLOCKERS |
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