NOVEL TRICYCLIC DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
The present invention relates to a novel tricyclic derivative with efficient inhibitory activity against poly(ADP-ribose)polymerases (PARP) or pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition containing the same. The tricyclic derivative of th...
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| Main Authors | , , , , , , , , , , , , |
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| Format | Patent |
| Language | English Portuguese |
| Published |
07.01.2014
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The present invention relates to a novel tricyclic derivative with efficient inhibitory activity against poly(ADP-ribose)polymerases (PARP) or pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition containing the same. The tricyclic derivative of the invention is useful for the prevention or treatment of diseases caused by excess PARP activity, especially neuropathic pain, neurodegenerative diseases, cardiovascular diseases, diabetic nephropathy, inflammatory diseases, osteoporosis, and cancer, by inhibiting the activity of poly(ADP-ribose)polymerases. |
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| AbstractList | The present invention relates to a novel tricyclic derivative with efficient inhibitory activity against poly(ADP-ribose)polymerases (PARP) or pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition containing the same. The tricyclic derivative of the invention is useful for the prevention or treatment of diseases caused by excess PARP activity, especially neuropathic pain, neurodegenerative diseases, cardiovascular diseases, diabetic nephropathy, inflammatory diseases, osteoporosis, and cancer, by inhibiting the activity of poly(ADP-ribose)polymerases. |
| Author | CHOI JI-SO KU SAE-KWANG PARK JI-SEON KIM YOUNGUL KIM SEUNG-HYUN CHUN KWANG-WOO ANTONIO INFANTE DA CAMARA TRIGUEIROS DE ARAGAO YE IN-HAE CHOI JONG-HEE LEE HANANG KIM MYUNG-HWA PARK CHUN-HO RYU DONG-KYU |
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| DocumentTitleAlternate | NOVO DERIVADO TRICÍCLICO OU SEUS SAIS FARMACEUTICAMENTE ACEITÁVEIS, SEU MÉTODO DE PREPARAÇÃO, E COMPOSIÇÃO FARMACÊUTICA QUE O CONTÉM |
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| RelatedCompanies | JEIL PHARMACEUTICAL CO., LTD |
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| Snippet | The present invention relates to a novel tricyclic derivative with efficient inhibitory activity against poly(ADP-ribose)polymerases (PARP) or pharmaceutically... |
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| Title | NOVEL TRICYCLIC DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME |
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