N-TERMINALLY MONOPEGYLATED HUMAN GROWTH HORMONE CONJUGATES, PROCESS FOR THEIR PREPARATION, AND USE THEREOF

• Main Author: RORY F. FINN
• Format: Patent
• Language: English; Portuguese
• Published: 29.08.2007
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides a chemically modified human Growth Hormone (hGH) prepared by attaching a polyethylene glycol butyraldehyde moiety to the N-terminal phenylalanine of the protein. The chemically modified protein according to the present invention may have a much longer lasting hGH activ...