N-TERMINALLY MONOPEGYLATED HUMAN GROWTH HORMONE CONJUGATES, PROCESS FOR THEIR PREPARATION, AND USE THEREOF
The present invention provides a chemically modified human Growth Hormone (hGH) prepared by attaching a polyethylene glycol butyraldehyde moiety to the N-terminal phenylalanine of the protein. The chemically modified protein according to the present invention may have a much longer lasting hGH activ...
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| Main Author | |
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| Format | Patent |
| Language | English Portuguese |
| Published |
29.08.2007
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The present invention provides a chemically modified human Growth Hormone (hGH) prepared by attaching a polyethylene glycol butyraldehyde moiety to the N-terminal phenylalanine of the protein. The chemically modified protein according to the present invention may have a much longer lasting hGH activity than that of the un-modified hGH, enabling reduced dose and scheduling opportunities. The present invention also includes methods of use for the treatment and/or prevention of diseases or disorders in which use of growth hormone is beneficial. |
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| AbstractList | The present invention provides a chemically modified human Growth Hormone (hGH) prepared by attaching a polyethylene glycol butyraldehyde moiety to the N-terminal phenylalanine of the protein. The chemically modified protein according to the present invention may have a much longer lasting hGH activity than that of the un-modified hGH, enabling reduced dose and scheduling opportunities. The present invention also includes methods of use for the treatment and/or prevention of diseases or disorders in which use of growth hormone is beneficial. |
| Author | RORY F. FINN |
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| Discipline | Medicine Chemistry Sciences |
| DocumentTitleAlternate | CONJUGADOS DA HORMONA DE CRESCIMENTO HUMANA MONOPEGILADA N-TERMINALMENTE, PROCESSO PARA A SUA PREPARAÇÃO E MÉTODOS PARA UTILIZAÇÃO DESTES |
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| Notes | Application Number: PT20050702331T |
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| PublicationDateYYYYMMDD | 2007-08-29 |
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| RelatedCompanies | PHARMACIA CORPORATION |
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| Snippet | The present invention provides a chemically modified human Growth Hormone (hGH) prepared by attaching a polyethylene glycol butyraldehyde moiety to the... |
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| SubjectTerms | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| Title | N-TERMINALLY MONOPEGYLATED HUMAN GROWTH HORMONE CONJUGATES, PROCESS FOR THEIR PREPARATION, AND USE THEREOF |
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