ALLERGY VACCINE COMPOSITION, PRODUCTION METHOD THEREOF AND USE OF SAME IN ALLERGY TREATMENT

• Main Authors: CLAUDIO RODRIGUEZ MARTINEZ, OLIVER GERMAN PEREZ MARTIN, VICTORIANO GUSTAVO SIERRA GONZALEZ, IGOR BIDOT MARTINEZ, GUSTAVO RAFAEL BRACHO GRANADA, ELISA FACENDA RAMOS, CARIDAD ZAYAS VIGNIER, MIRIAM DE SAN JUAN LASTRE GONZALEZ, JORGE ERNESTO PEREZ LASTRE, DAINERYS ALEIDA PEREZ LASTRE, ALEXIS LABRADA ROSADO, JUDITH MONICA DEL CAMPO ALONSO
• Format: Patent
• Language: English; Portuguese
• Published: 27.09.2011
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention rebates to the field of Immunology, specifically with the branch of Immuno-Allergy and in particular with the use of adjuvant or carrier compounds, capable of modulating the immune response to allergens. The technical objective that is pursued is to obtain a pharmaceutical preparation of therapeutic or prophylactic use using bacterial proteoliposomes, which transform the allergic response Th2 and IgE when being applied in allergic individuals, toward a protector response Th1; as well as it is able to prevent the appearance and the development of allergies in individuals non-allergic yet. The vaccine composition consists of proteoliposomes derived from Gram-negative bacteria coupled to allergens and optionally contains other adjuvants or antigens. The method for its preparation and an immunization scheme of two doses are provided.