INIBIDORES DA PRIMASE DO VHS

• Main Authors: MICHELE LIUZZI, BRUNO SIMONEAU, ANTON MENTRUP
• Format: Patent
• Language: Portuguese
• Published: 31.03.2004
• Edition: 7
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides compounds of the formula 1 that are active against the HSV primase enzyme:whereinR1 is hydroxy or amino;R2 is hydrogen, halo, (C1-4)alkyl or (C1-4)alkoxy; R3 is hydrogen, halo, (C1-4)alkyl, (C1-4)alkoxy, amino or azido; R4 has the same significance as R2;R5 is hydrogen or (C1-...