COMPOSTOS DE INDOLE CONTENDO SULFONAMIDA

• Main Authors: TSUKAHARA, NAOKO, OKABE, TADASHI, FUNAHASHI, YASUHIRO, SEMBA, TARO, HANEDA, TORU, UEDA, NORIHIRO, TSURUOKA, AKIHIKO, OZAWA, YOICHI, WAKABAYASHI, TOSHIAKI, KAMATA, JUNICHI, NARA, KAZUMASA, HATA, NAOKO, OWA, TAKASHI, HAMAOKA, SHINICHI, TAKAHASHI, KEIKO, YAMAMOTO, YUJI
• Format: Patent
• Language: Portuguese
• Published: 31.07.2006
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Novel neovascularization inhibitors are constructed to provide antitumor agents which are superior in safety to conventional antitumor agents, are surely efficacious and can be administered over a prolonged period of time. Namely, indole compounds represented by general formula (I) or pharmacologically acceptable salts thereof or hydrates of the same wherein R represents hydrogen, etc.; R and R are the same or different and each represents hydrogen, etc.; R represents hydrogen or lower (C1-4) alkyl; and the ring A represents cyanophenyl, etc., provided that the following cases are excluded; the one where R , R and R are all hydrogen atoms; the one where R and R are both hydrogen atoms; and the one where the ring A is an aminosulfonylphenyl group and R and R are both halogen atoms; and provided that when the ring A is a cyanophenyl, 2-amino-5-pyridyl or 2-halogeno-5-pyridyl group and R is a cyano group or a halogen atom, then at least one of R and R is not hydrogen.