CONTROLLED SYNTHESIS OF ZIPRASIDONE AND COMPOSITIONS THEREOF

• Main Authors: BUSCH FRANK ROBERT, LEEMAN KYLE ROBERT, HOWARD HARRY RALPH JR, GROBIN ADAM WORTH
• Format: Patent
• Language: English; Polish
• Published: 11.07.2005
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The subject invention provides a ziprasidone composition that comprises not greater than 1000 ppm des-chloro ziprasidone, preferably not greater than about 500 ppm des-chloro ziprasidone, and more preferably not greater than about 100 ppm des-chloro ziprasidone. Methods for synthesizing and using su...