PROCESS FOR PREPARATION OF $G(A)-HYDROXYCARBOXYLIC ACID AMIDES

The invention concerns a novel process for the preparation of 2-phenyl-2-hydroxy-N-Ä2-(3-alkoxy-4-hydroxyphenyl)-ethylÜ-acetamides of the formula I wherein R1 is alkyl, R2, and R3 are each independently hydrogen or alkyl, and R4, is optionally substituted aryl or optionally substituted heteroaryl, w...

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Main Authors FABER DOMINIK, LAMBERTH CLEMENS, ZELLER MARTIN, VETTIGER THOMAS
Format Patent
LanguageEnglish
Polish
Published 21.03.2005
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Abstract The invention concerns a novel process for the preparation of 2-phenyl-2-hydroxy-N-Ä2-(3-alkoxy-4-hydroxyphenyl)-ethylÜ-acetamides of the formula I wherein R1 is alkyl, R2, and R3 are each independently hydrogen or alkyl, and R4, is optionally substituted aryl or optionally substituted heteroaryl, which process comprises reacting a 2-(3-alkoxy-4-hydroxyphenyl)-ethylamine of the formula II wherein R1 R2 and R3 are as defined above with a alpha -hydoxycarboxylic acid ester of the formula III or a dioxolanone of the formula IIIa wherein R4 is as defined above, and R5, R6 and R7 independently of each other are lower alkyl. The compounds of formula I are important intermediates for a novel group of fungicides derived from mandelic acid amides.
AbstractList The invention concerns a novel process for the preparation of 2-phenyl-2-hydroxy-N-Ä2-(3-alkoxy-4-hydroxyphenyl)-ethylÜ-acetamides of the formula I wherein R1 is alkyl, R2, and R3 are each independently hydrogen or alkyl, and R4, is optionally substituted aryl or optionally substituted heteroaryl, which process comprises reacting a 2-(3-alkoxy-4-hydroxyphenyl)-ethylamine of the formula II wherein R1 R2 and R3 are as defined above with a alpha -hydoxycarboxylic acid ester of the formula III or a dioxolanone of the formula IIIa wherein R4 is as defined above, and R5, R6 and R7 independently of each other are lower alkyl. The compounds of formula I are important intermediates for a novel group of fungicides derived from mandelic acid amides.
Author LAMBERTH CLEMENS
FABER DOMINIK
VETTIGER THOMAS
ZELLER MARTIN
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Snippet The invention concerns a novel process for the preparation of 2-phenyl-2-hydroxy-N-Ä2-(3-alkoxy-4-hydroxyphenyl)-ethylÜ-acetamides of the formula I wherein R1...
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Title PROCESS FOR PREPARATION OF $G(A)-HYDROXYCARBOXYLIC ACID AMIDES
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