AROMATIC SULFONE HYDROXAMATES AND THEIR USE AS PROTEASE INHIBITORS

• Main Authors: FOBIAN YVETTE M, WANG LIJUAN JANE, RICO JOSEPH G, KASSAB DARREN J, BARTA THOMAS E, BECKER DANIEL P, CARROLL JEFFREY N, BOEHM TERRI L, TALLEY JOHN J, VILLAMIL CLARA I, DECRESCENZO GARY A, MISCHKE DEBORAH A, HOCKERMAN SUSAN L, NORTON MONICA B, BEDELL LOUIS J, FRESKOS JOHN N, MCDONALD JOSEPH J, KOLODZIEJ STEVE A
• Format: Patent
• Language: English; Polish
• Published: 21.02.2005
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

This invention is directed to aromatic sulfone hydroxamic acids (including hydroxamates) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as "matrix metalloprotease" or "MMP") activity and/or aggrecanase activity. This invention also is directed to...