SYNTHESIS OF TRANS-8-CHLORO-5-METHYL-1 -[4-(PYRIDIN-2-YLOXY)-CYCLOHEXYL]-5,6-DIHYDRO-4H-2,3,5,10B-TETRAAZA-BENZO[E]AZULENE AND CRYTALLINE FORMS THEREOF

The invention provides processes to manufacture substituted 1-[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes. Also disclosed are compounds useful as intermediates in the methods of the invention.

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Bibliographic Details
Main Authors TRUSSARDI, RENÉ, HOFFMANN-EMERY, FABIENNE, PFLEGER, CHRISTOPHE, BARTELS, BJOERN, ROTHENHAEUSLER, BENNO, GRASSMANN, OLAF, HARTUNG, THOMAS, ADAM, JEAN-MICHEL, SCHWITTER, URS, RAN, FREDERIC, DIODONE, RALPH
Format Patent
LanguageEnglish
Polish
Published 04.10.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract The invention provides processes to manufacture substituted 1-[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes. Also disclosed are compounds useful as intermediates in the methods of the invention.
AbstractList The invention provides processes to manufacture substituted 1-[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes. Also disclosed are compounds useful as intermediates in the methods of the invention.
Author TRUSSARDI, RENÉ
HOFFMANN-EMERY, FABIENNE
ADAM, JEAN-MICHEL
BARTELS, BJOERN
RAN, FREDERIC
DIODONE, RALPH
SCHWITTER, URS
HARTUNG, THOMAS
PFLEGER, CHRISTOPHE
ROTHENHAEUSLER, BENNO
GRASSMANN, OLAF
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– fullname: HOFFMANN-EMERY, FABIENNE
– fullname: PFLEGER, CHRISTOPHE
– fullname: BARTELS, BJOERN
– fullname: ROTHENHAEUSLER, BENNO
– fullname: GRASSMANN, OLAF
– fullname: HARTUNG, THOMAS
– fullname: ADAM, JEAN-MICHEL
– fullname: SCHWITTER, URS
– fullname: RAN, FREDERIC
– fullname: DIODONE, RALPH
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DocumentTitleAlternate SYNTEZA TRANS-8-CHLORO-5-METYLO-1-[4-(PIRYDYN-2-YLOKSY)¬CYKLOHEKSYLO]-5,6-DIHYDRO-4H-2,3,5,10B-TETRAAZABENZO[E]¬AZULENU I JEGO POSTACI KRSYTALICZNYCH
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RelatedCompanies F. Hoffmann-La Roche AG
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Snippet The invention provides processes to manufacture substituted 1-[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes. Also...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title SYNTHESIS OF TRANS-8-CHLORO-5-METHYL-1 -[4-(PYRIDIN-2-YLOXY)-CYCLOHEXYL]-5,6-DIHYDRO-4H-2,3,5,10B-TETRAAZA-BENZO[E]AZULENE AND CRYTALLINE FORMS THEREOF
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