METHODS OF ISOLATING 4-CHLORO-2-FLUORO-3-SUBSTITUTED-PHENYLBORONIC ACIDS
Provided herein are methods of isolating a 4-chloro-2-fluoro-3-substituted-phenylboronic acid. The method comprises contacting a mixture of water, a water-miscible organic solvent, and a 4-chloro-2-fluoro-3-substituted-phenylboronic acid with a salt to form a water-miscible organic solvent layer and...
Saved in:
Main Author | |
---|---|
Format | Patent |
Language | English Polish |
Published |
30.11.2018
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Provided herein are methods of isolating a 4-chloro-2-fluoro-3-substituted-phenylboronic acid. The method comprises contacting a mixture of water, a water-miscible organic solvent, and a 4-chloro-2-fluoro-3-substituted-phenylboronic acid with a salt to form a water-miscible organic solvent layer and a water layer. The 4-chloro-2-fluoro-3-substituted-phenylboronic acid is partitioned into the water-miscible organic solvent layer, which is separated from the water layer. Additional methods are disclosed, as is a 4-chloro-2-fluoro-3-substituted-phenylboronic acid produced by one of the methods, wherein the 4-chloro-2-fluoro-3-substituted-phenylboronic acid is obtained at a yield of greater than approximately 90%. |
---|---|
AbstractList | Provided herein are methods of isolating a 4-chloro-2-fluoro-3-substituted-phenylboronic acid. The method comprises contacting a mixture of water, a water-miscible organic solvent, and a 4-chloro-2-fluoro-3-substituted-phenylboronic acid with a salt to form a water-miscible organic solvent layer and a water layer. The 4-chloro-2-fluoro-3-substituted-phenylboronic acid is partitioned into the water-miscible organic solvent layer, which is separated from the water layer. Additional methods are disclosed, as is a 4-chloro-2-fluoro-3-substituted-phenylboronic acid produced by one of the methods, wherein the 4-chloro-2-fluoro-3-substituted-phenylboronic acid is obtained at a yield of greater than approximately 90%. |
Author | OPPENHEIMER, JOSSIAN |
Author_xml | – fullname: OPPENHEIMER, JOSSIAN |
BookMark | eNrjYmDJy89L5WTw8HUN8fB3CVbwd1PwDPb3cQzx9HNXMNF19vDxD_LXNdJ18wkFMYx1g0OdgkM8Q0JDXF10Azxc_SJ9nIASfp7OCo7Oni7BPAysaYk5xam8UJqbQdHNNcTZQze1ID8-tbggMTk1L7UkPsDHyNzYzNLQKCTE2JgYNQA02S8r |
ContentType | Patent |
DBID | EVB |
DatabaseName | esp@cenet |
DatabaseTitleList | |
Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Chemistry Sciences |
DocumentTitleAlternate | Sposoby izolowania kwasów 4-chloro-2-fluoro-3-podstawionych-fenyloboronowych |
ExternalDocumentID | PL2736912TT3 |
GroupedDBID | EVB |
ID | FETCH-epo_espacenet_PL2736912TT33 |
IEDL.DBID | EVB |
IngestDate | Fri Jul 19 13:59:33 EDT 2024 |
IsOpenAccess | true |
IsPeerReviewed | false |
IsScholarly | false |
Language | English Polish |
LinkModel | DirectLink |
MergedId | FETCHMERGED-epo_espacenet_PL2736912TT33 |
Notes | Application Number: PL20120817070T |
OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20181130&DB=EPODOC&CC=PL&NR=2736912T3 |
ParticipantIDs | epo_espacenet_PL2736912TT3 |
PublicationCentury | 2000 |
PublicationDate | 20181130 |
PublicationDateYYYYMMDD | 2018-11-30 |
PublicationDate_xml | – month: 11 year: 2018 text: 20181130 day: 30 |
PublicationDecade | 2010 |
PublicationYear | 2018 |
RelatedCompanies | Dow AgroSciences LLC |
RelatedCompanies_xml | – name: Dow AgroSciences LLC |
Score | 3.182881 |
Snippet | Provided herein are methods of isolating a 4-chloro-2-fluoro-3-substituted-phenylboronic acid. The method comprises contacting a mixture of water, a... |
SourceID | epo |
SourceType | Open Access Repository |
SubjectTerms | ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY METALLURGY ORGANIC CHEMISTRY |
Title | METHODS OF ISOLATING 4-CHLORO-2-FLUORO-3-SUBSTITUTED-PHENYLBORONIC ACIDS |
URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20181130&DB=EPODOC&locale=&CC=PL&NR=2736912T3 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fS8MwED7mFPVNp6LzBxWkb8Fu7druociatrbSNWVNZT6Npt1gINtwFf99r3VTX_QtJHBcAvd9uST3BeCumOaiJzSddPLCIFolgmkqukJyUeSZoouZVj_GHEa6n2pP4964AfNtLUytE_pRiyNiROUY72WN16ufQyynflu5vhdz7Fo-eNxy5E12jHSFmCw7tuXGzGFUptSKQzkaWcjSer_T5eoO7Fa76Epm3322q6KU1W9G8Y5gL0Zji_IYGqvXFhzQ7cdrLdgfbu67sbkJvfUJ-EOX-8xJJOZJQcLCAQ-iR0kj1A_ZiJEu8cK0aqgkSe2EBzxFTCKx70YvoY0DUUClAQ2c5BRuPZdTn6BLk-_pT-Jw6zxX1TNoLpaL6TlIplHMlEIvdLOPOa4wMmRbTC8Q3MwM0x7jAtp_22n_N3gJh9VSfgkcXkGzfHufXiP1luKmXrRP-Z6B1Q |
link.rule.ids | 230,309,786,891,25594,76903 |
linkProvider | European Patent Office |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LS8NAEB5qFetNq6L1FUFyW0ybNEkPQZpNYqKbB81G2lNpkhYK0hYb8e87ia160duwA8PswszHtzszC3CXT7O0myoqaWe5RpRyCKYuqRLJ0jybSGo6U6piTD9Q3UR5GnaHNZhve2GqOaEf1XBEjKgM472o8vXq5xLLqmor1_fpHJeWDw43LHHDjhGuMCeLlmnYUWiFVKTUiJgYDAxEabXX7nB5B3Y1ZIQVU3oxy6aU1W9EcQ5hL0Jji-IIaqvXJjTo9uO1Juz7m_duFDehtz4G17e5G1qxEDqCF4esz73gUVAIdVk4CEmHOCwpBZnEiRlzjyeYk0jk2sGImagIPCr0qWfFJ3Dr2Jy6BF0af29_HLGt81yWT6G-WC6mZyDoWj6TcjVX9R5y3FSbINoivcDkpk-Q9mjn0PrbTus_5Q00XO6zMfOC5ws4KI_1a9jhJdSLt_fpFcJwkV5XB_gJMN-Evw |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=METHODS+OF+ISOLATING+4-CHLORO-2-FLUORO-3-SUBSTITUTED-PHENYLBORONIC+ACIDS&rft.inventor=OPPENHEIMER%2C+JOSSIAN&rft.date=2018-11-30&rft.externalDBID=T3&rft.externalDocID=PL2736912TT3 |