PROCESS FOR THE PRODUCTION OF TERT-BUTYL (E)-(6-[2- [4-(4-FLUOROPHENYL) -6-ISOPROPYL-2-[ METHYL (METHYLSULFONYL) AMINO] PYRIMIDIN-5-YL] VINYL](4R, 6S)-2,2-DIMETHYL [1,3]DIOXAN-4-YL) ACETATE

The invention concerns a process for the manufacture of tert-butyl (E)-(6-[2-4-(4-flourophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]vinyl)-(4R,6S)-2,2-dimethyl[1,3]-dioxan-4-yl)acetate, the novel starting material used in said process and the use of the process in the manufactu...

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Main Authors KOIKE HARUO, DIORAZIO LOUIS JOSEPH, KABAKI MIKIO, TAYLOR NIGEL PHILIP
Format Patent
LanguageEnglish
Polish
Published 31.12.2014
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract The invention concerns a process for the manufacture of tert-butyl (E)-(6-[2-4-(4-flourophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]vinyl)-(4R,6S)-2,2-dimethyl[1,3]-dioxan-4-yl)acetate, the novel starting material used in said process and the use of the process in the manufacture of a pharmaceutical.
AbstractList The invention concerns a process for the manufacture of tert-butyl (E)-(6-[2-4-(4-flourophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]vinyl)-(4R,6S)-2,2-dimethyl[1,3]-dioxan-4-yl)acetate, the novel starting material used in said process and the use of the process in the manufacture of a pharmaceutical.
Author DIORAZIO LOUIS JOSEPH
KOIKE HARUO
TAYLOR NIGEL PHILIP
KABAKI MIKIO
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DocumentTitleAlternate Sposób wytwarzania kwasu (E) -7-[4- (4 - fluorofenylo) - 6- izopropylo-2-[metylo (metylosulfonylo) amino] pirymidyn -5-ylo] (3R,5S) -3,5-dihydroksyhept-6-enowego i/lub jego farmaceutycznie dopuszczalnych soli oraz stosowany półprodukt i substrat
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RelatedCompanies SHIONOGI & CO. LTD
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Snippet The invention concerns a process for the manufacture of tert-butyl...
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HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title PROCESS FOR THE PRODUCTION OF TERT-BUTYL (E)-(6-[2- [4-(4-FLUOROPHENYL) -6-ISOPROPYL-2-[ METHYL (METHYLSULFONYL) AMINO] PYRIMIDIN-5-YL] VINYL](4R, 6S)-2,2-DIMETHYL [1,3]DIOXAN-4-YL) ACETATE
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