HETEROARYLPHENOXY BENZAMIDE KAPPA OPIOID LIGANDS

The present invention provides compounds of Formula I: and pharmaceutically acceptable salts thereof wherein the variables R1, R2, R3, R4, R9, X, m and n are as defined herein; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compound s or...

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Bibliographic Details
Main Authors MENTE, Scot Richard, BRODNEY, Michael Aaron, KAUFFMAN, Gregory Wayne, MONTGOMERY, Justin Ian, VERHOEST, Patrick Robert, DUNN, Matthew Francis, RANKIC, Danica Antonia, ROGERS, Bruce Nelsen, ARORA, Kapildev Kashmirilal, GREEN, Michael Eric, KABLAOUI, Natasha Mariam
Format Patent
LanguageEnglish
Published 11.12.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides compounds of Formula I: and pharmaceutically acceptable salts thereof wherein the variables R1, R2, R3, R4, R9, X, m and n are as defined herein; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compound s or s al ts, an d thei r uses for treating kappa opioid (?-opioid) associated disorders including, e.g., a neurological disorder, or psychiatric disorder such as a neurocognitive disorder, substance abuse disorder, depressive disorder, anxiety disorder, trauma and stressor related disorder and feeding and eating disorder.
Bibliography:Application Number: PH20191501172