PYRIDINE DERIVATIVES AS REARRANGED DURING TRANSFECTION (RET) KINASE INHIBITORS

• Main Authors: EIDAM, HILARY SCHENCK, GUAN, AMY HUIPING, DEMARTINO, MICHAEL P, GONG, ZHEN, WU, CHENGDE, CHEUNG, MUI, RAHA, KAUSHIK, YANG, HAIYING, YU, HAIYU, ZHANG, ZHILIU
• Format: Patent
• Language: English
• Published: 18.01.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensi...