COMPOSICIONES DE ANTICUERPOS Y METODOS DE USO DE LOS MISMOS
La presente invencion proporciona composiciones farmaceuticas que comprenden (i) un anticuerpo que se une especificamente a PD-1, (ii) una enzima endoglicosidasa hidrolasa y (iii) al menos dos antioxidantes, seleccionados de metionina y acido pentetico "DTPA", o, metionina y EDTA. En algun...
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Format | Patent |
Language | Spanish |
Published |
18.04.2024
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Abstract | La presente invencion proporciona composiciones farmaceuticas que comprenden (i) un anticuerpo que se une especificamente a PD-1, (ii) una enzima endoglicosidasa hidrolasa y (iii) al menos dos antioxidantes, seleccionados de metionina y acido pentetico "DTPA", o, metionina y EDTA. En algunos aspectos, la enzima endoglicosidasa hidrolasa escinde el acido hialuronico en un enlace beta (1-4) o (1-3) hexosaminidico; comprende una hialuronidasa seleccionada del grupo que consiste en HuPH20, HYAL1, HYAL2, HYAL3, HYAL4, o cualquier variante y cualquier isoforma de las mismas; y presenta a rHuPH20 o un fragmento de la misma. Ademas, dichas composiciones comprenden sacarosa como un modificador de tonicidad, histidina como agente tamponador, o polisorbato 80 como tensioactivo. La presente tambien reivindica metodos de administracion subcutanea de las composiciones y la dosis unitaria comprendida en un vial, jeringa, autoinyector o dispositivo portatil.
The disclosure provides pharmaceutical compositions comprising an antibody and at least two antioxidants. In some aspects, pharmaceutical composition is formulated for subcutaneous delivery. In some aspects, the pharmaceutical composition further comprises an endoglycosidase hydrolase enzyme. Other aspects of the present disclosure are directed to methods of subcutaneously delivering the pharmaceutical composition. |
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AbstractList | La presente invencion proporciona composiciones farmaceuticas que comprenden (i) un anticuerpo que se une especificamente a PD-1, (ii) una enzima endoglicosidasa hidrolasa y (iii) al menos dos antioxidantes, seleccionados de metionina y acido pentetico "DTPA", o, metionina y EDTA. En algunos aspectos, la enzima endoglicosidasa hidrolasa escinde el acido hialuronico en un enlace beta (1-4) o (1-3) hexosaminidico; comprende una hialuronidasa seleccionada del grupo que consiste en HuPH20, HYAL1, HYAL2, HYAL3, HYAL4, o cualquier variante y cualquier isoforma de las mismas; y presenta a rHuPH20 o un fragmento de la misma. Ademas, dichas composiciones comprenden sacarosa como un modificador de tonicidad, histidina como agente tamponador, o polisorbato 80 como tensioactivo. La presente tambien reivindica metodos de administracion subcutanea de las composiciones y la dosis unitaria comprendida en un vial, jeringa, autoinyector o dispositivo portatil.
The disclosure provides pharmaceutical compositions comprising an antibody and at least two antioxidants. In some aspects, pharmaceutical composition is formulated for subcutaneous delivery. In some aspects, the pharmaceutical composition further comprises an endoglycosidase hydrolase enzyme. Other aspects of the present disclosure are directed to methods of subcutaneously delivering the pharmaceutical composition. |
Author | MANTRI, Rao Venkatramana KHOSSRAVI, Mehrnaz MURTHY, Bindu Purnima ARAS, Urvi Ashish SANGHAVI, Kinjal HABY, Thomas Arthur HART, Scott Aaron ZHAO, Xiaochen BELLO, Akintunde HUANG, Masano ROY, Amit VEZINA, Heather Elizabeth |
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Snippet | La presente invencion proporciona composiciones farmaceuticas que comprenden (i) un anticuerpo que se une especificamente a PD-1, (ii) una enzima... |
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Title | COMPOSICIONES DE ANTICUERPOS Y METODOS DE USO DE LOS MISMOS |
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