UNA COMPOSICION FARMACEUTICA QUE COMPRENDE ACIDO 1-(3-CIANO-1-ISOPROPIL-INDOL-5-IL)PIRAZOL-4-CARBOXILICO

• Main Authors: GWAK, Heemin, LEE, Jieun, SHIN, Seong Hye, KIM, Junyu, MIN, Ji Young, MUNE, June Sik, KIM, Min Hee, SEO, Jung Youn
• Format: Patent
• Language: Spanish
• Published: 16.02.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

La presente invencion se refiere a una composicion farmaceutica que comprende acido 1-(3-ciano-1-isopropil-indol-5-il)pirazol-4-carboxilo o una sal farmaceuticamente aceptable del mismo, para ser administrada por via oral a un sujeto en una dosificacion de 50 a 200 mg/dia, donde el sujeto tiene una tasa de filtracion glomerular estimada (eGFR) de menos de 90 mL/min/1,73 m2. Dicha composicion es util para tratar o prevenir una enfermedad relacionada con la hiperuricemia, tal como es gota, exacerbacion de gota recurrente, artritis gotosa, hipertension, enfermedad cardiovascular, cardiopatia coronaria, entre otras. The present invention relates to a pharmaceutical composition comprising 1-(3-cyano-1-isopropyl-indol-5-yl)pyrazol-4-carboxylic acid or a pharmaceutically acceptable salt thereof, and a method of treating or preventing a hyperuricemia-related disease using the same, and the pharmaceutical composition of the present invention may effectively reduce the blood uric acid concentration in a patient with a hyperuricemia-related disease.