MOLECULAS DE UNION PARA BCMA Y CD3

• Main Authors: RAU, DORIS, BORGES, ERIC, KUFER, PETER, HIPP, SUSANNE, HOFFMANN, PATRICK, LUTTERBUESE, RALF, HEBEIS, BARBARA, KISCHEL, ROMAN, RAUM, TOBIAS, ADAM, PAUL
• Format: Patent
• Language: Spanish
• Published: 20.12.2015
• Subjects: CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES

La presente invencion se refiere a una molecula de union que comprende un primer y un segundo dominio de union, en donde el primer dominio de union es capaz de unirse al cluster de epitopes de BCMA, y el segundo dominio de union es capaz de unirse al complejo del receptor CD3 de celulas T. Mas aun, la invencion provee una secuencia de acido nucleico que codifica la molecula de union, un vector que comprende dicha secuencia de acido nucleico y una celula hospedadora transformada o transfectada con dicho vector. Adicionalmente, la invencion provee un proceso para la produccion de la molecula de union de la invencion, un uso medico de dicha molecula de union y un kit que comprende dicha molecula de union The present invention relates to a binding molecule comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope clusters of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.