Humanized, mouse or chimeric anti-cd47 monoclonal antibodies

• Main Authors: Lahmar, Mehdi, Fallot, Stéphanie, Châlons-Cottavoz, Marie, Schwamborn, Klaus, Beltraminelli, Nicola, Garrone, Pierre
• Format: Patent
• Language: English
• Published: 30.08.2024
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Humanized, mouse or chimeric anti-CD47 monoclonal antibodies are provided. The antibodies bind to human glycosylated and deglycosylated CD47 with an optimized Koff value, they disrupt the human CD47-SIRPα interaction, and find use in various therapeutic, preventive or diagnostic methods. The inventi...